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Descritor Inglês:   Histone Deacetylases 
Descritor Espanhol:   Histona Desacetilasas 
Descritor Português:   Histona Desacetilases 
Sinônimos Inglês:   Class I Histone Deacetylases
Class II Histone Deacetylases
Complexes, Histone Deacetylase
Deacetylase Complexes, Histone
Deacetylase, Histone
Deacetylases, Histone
HDAC Proteins
Histone Deacetylase
Histone Deacetylase Complexes  
Categoria:   D08.811.277.087.520
Definição Inglês:   Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes. 
Combinados Inglês:   Histone Deacetylases/antagonists & inhibitors use Histone Deacetylase Inhibitors
Nota Histórica Inglês:   2003; use AMIDOHYDROLASES 1975-1990 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   6816 
Identificador Único:   D006655 

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