Pesquisa sobre: INSULIN RECEPTOR SUBSTRATE PROTEINS 
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Descritor Inglês:   Insulin Receptor Substrate Proteins 
Descritor Espanhol:   Proteínas Sustrato del Receptor de Insulina 
Descritor Português:   Proteínas Substratos do Receptor de Insulina 
Sinônimos Inglês:   IRS Signaling Adaptor Proteins
Insulin Receptor Substrate 1
Insulin Receptor Substrate 1 Protein
Insulin Receptor Substrate 2
Insulin Receptor Substrate 2 Protein
Insulin Receptor Substrate 3
Insulin Receptor Substrate 3 Protein
Insulin Receptor Substrate 4
Insulin Receptor Substrate 4 Protein
Insulin Receptor Substrate-1
Insulin Receptor Substrate-1 Protein
Insulin Receptor Substrate-2
Insulin Receptor Substrate-2 Protein
Insulin Receptor Substrate-3
Insulin Receptor Substrate-3 Protein
Insulin Receptor Substrate-4
Insulin Receptor Substrate-4 Protein  
Categoria:   D12.644.360.024.301
D12.776.157.057.045
D12.776.476.024.382
Definição Inglês:   A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. 
Nota Histórica Inglês:   2009(1992) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   53148 
Identificador Único:   D055504 

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