Pesquisa sobre: INTEGRINS 
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Descritor Inglês:   Integrins 
Descritor Espanhol:   Integrinas 
Descritor Português:   Integrinas 
Categoria:   D12.776.543.750.705.408
Definição Inglês:   A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. 
Nota de Indexação Inglês:   prefer specifics
Relacionados Inglês:   Cell Adhesion Molecules
Nota Histórica Inglês:   90 
Qualificadores Permitidos Inglês:  
AD administration & dosage AG agonists
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CH chemistry
CL classification DF deficiency
DE drug effects GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PH physiology RE radiation effects
TU therapeutic use UL ultrastructure
Número do Registro:   24746 
Identificador Único:   D016023 

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