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Descriptor English: Loratadine
Descriptor Spanish: Loratadina
Descriptor loratadina
Scope note: Antagonista de segunda generación de los receptores de histamina H1 utilizada en el tratamiento de la rinitis alérgica y de la urticaria. A diferencia de la mayoría de los antihistamínicos clásicos (ANTAGONISTAS DE HISTAMINA H1) carece de los efectos depresores del sistema nervioso central como somnolencia.
Descriptor Portuguese: Loratadina
Descriptor French: Loratadine
Entry term(s): 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
Alavert
Claritin
Clarium
Sch 29851
Sch-29851
Sch29851
Tree number(s): D02.455.426.559.847.181.384.340.500
D03.383.621.160.500
D04.615.181.384.340.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017336
Scope note: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antipruritics
Anti-Allergic Agents
Histamine H1 Antagonists, Non-Sedating
Registry Number: 7AJO3BO7QN
CAS Type 1 Name: 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
Previous Indexing: Cyproheptadine/analogs & derivatives (1987-1992)
Piperidines (1984-1986)
Public MeSH Note: 93; LORATADINE was indexed under CYPROHEPTADINE/analogs & derivatives 1976-92 & PIPERIDINES 1984-86
Online Note: use LORATADINE (NM) to search LORATADINE 1984-92
History Note: 93; was LORATADINE (NM) 1984-92
DeCS ID: 30666
Unique ID: D017336
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/22
Revision Date: 2017/05/24
Loratadine - Preferred
Concept UI M0026329
Scope note A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Preferred term Loratadine
Entry term(s) 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
Claritin - Narrower
Concept UI M0350542
Preferred term Claritin
Sch-29851 - Narrower
Concept UI M0350544
Preferred term Sch-29851
Entry term(s) Sch 29851
Sch29851
Alavert - Narrower
Concept UI M0446775
Preferred term Alavert
Clarium - Narrower
Concept UI M0350543
Preferred term Clarium



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