Pesquisa sobre: LOVASTATIN 
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Descritor Inglês:   Lovastatin 
Descritor Espanhol:   Lovastatina 
Descritor Português:   Lovastatina 
Sinônimos Inglês:   1 alpha-Isomer Lovastatin
6 Methylcompactin
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha Isomer
Lovastatin, 1 alpha-Isomer
MK 803
Monacolin K
alpha-Isomer Lovastatin, 1  
Categoria:   D02.455.426.559.847.638.400
Definição Inglês:   A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. 
Ação Farmacológica:   Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Nota Histórica Inglês:   88; for MONACOLIN K use LOVASTATIN (NM) 1980-98 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Número do Registro:   22932 
Identificador Único:   D008148 

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