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Descriptor English: Mifepristone
Descriptor Spanish: Mifepristona
Descriptor mifepristona
Scope note: Antagonista de las hormonas progestágenas y glucocorticoides. Su inhibición de la progesterona induce la hemorragia en la fase luteínica y en la fase inicial del embarazo a través de la liberación de prostaglandinas endógenas del endometrio o la decidua. Como antagonista de los receptores de glucocorticoides, este fármaco se ha utilizado para tratar el hipercortisolismo en pacientes con SÍNDROME DE CUSHING no hipofisario.
Descriptor Portuguese: Mifepristona
Descriptor French: Mifépristone
Entry term(s): Mifegyne
Mifeprex
Mifégyne
R 38486
R-38486
R38486
RU 38486
RU 486
RU-38486
RU-486
RU38486
RU486
ZK 98296
ZK-98296
ZK98296
Tree number(s): D04.210.500.365.415.580
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015735
Scope note: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Abortifacient Agents, Steroidal
Contraceptives, Oral, Synthetic
Contraceptives, Postcoital, Synthetic
Hormone Antagonists
Luteolytic Agents
Menstruation-Inducing Agents
Registry Number: 320T6RNW1F
CAS Type 1 Name: Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11beta,17beta)-
Previous Indexing: Abortifacient Agents, Steroidal (1975-1989)
Contraceptives, Oral, Synthetic (1975-1989)
Estrenes (1975-1989)
Glucocorticoids/antagonists & inhibitors (1967-1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24783
Unique ID: D015735
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/09/06
Revision Date: 2017/05/24
Mifepristone - Preferred
Concept UI M0024116
Scope note A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Preferred term Mifepristone
ZK-98296 - Related but not broader or narrower
Concept UI M0024117
Preferred term ZK-98296
Entry term(s) ZK 98296
ZK98296
R-38486 - Narrower
Concept UI M0351242
Preferred term R-38486
Entry term(s) R 38486
R38486
RU 38486
RU 486
RU-38486
RU-486
RU38486
RU486
Mifegyne - Narrower
Concept UI M0474322
Preferred term Mifegyne
Entry term(s) Mifégyne
Mifeprex - Narrower
Concept UI M0474323
Preferred term Mifeprex



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