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Descriptor English: Monocrotaline
Descriptor Spanish: Monocrotalina
Descriptor monocrotalina
Scope note: Alcaloide de pirrolizidina y constituyente de una planta tóxica que provoca envenenamiento del ganado y los seres humanos como consecuencia de la ingesta de granos contaminados y otros alimentos. El alcaloide causa hipertensión arterial pulmonar, hipertrofia del ventrículo derecho y alteraciones patológicas en la red vascular pulmonar. Tras el tratamiento oral con magnesio se ha observado una atenuación significativa de las alteraciones cardiopulmonares.
Descriptor Portuguese: Monocrotalina
Descriptor French: Monocrotaline
Entry term(s): Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer
Monocrotaline, (all-xi)-Isomer
Tree number(s): D03.132.716.500
D03.633.100.772.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016686
Scope note: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 73077K8HYV
CAS Type 1 Name: 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
Previous Indexing: Pyrrolizidine Alkaloids (1971-1973)
Public MeSH Note: 92; MONOCROTALINE was indexed under PYRROLIZIDINE ALKALOIDS 1973-91
Online Note: use MONOCROTALINE (NM) to search MONOCROTALINE 1980-91
History Note: 92; was MONOCROTALINE (NM) 1973-91
DeCS ID: 29959
Unique ID: D016686
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/25
Revision Date: 2016/05/31
Monocrotaline - Preferred
Concept UI M0025420
Scope note A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Preferred term Monocrotaline
Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer - Narrower
Concept UI M0329401
Preferred term Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer
Monocrotaline, (all-xi)-Isomer - Narrower
Concept UI M0329400
Preferred term Monocrotaline, (all-xi)-Isomer



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