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Descriptor English: Neuropilins
Descriptor Spanish: Neuropilinas
Descriptor neuropilinas
Entry term(s) neuropilina
Scope note: Las neuropilinas son receptores de la superficie celular de los vertebrados, de 140 kD, que se unen a moléculas de guía neuronal durante el desarrollo neural y el crecimiento axónico y modulan la angiogénesis mediada por VEGF. La NEUROPILINA-1 y la NEUROPILINA-2 difieren en sus especificidades de unión y se distribuyen de manera complementaria en regiones del sistema nervioso en desarrollo. Las neuropilinas son receptores de SEMAFORINAS DE CLASE 3 segregadas, así como de factores de crecimiento endotelial vascular y pueden formar hetero u homodímeros. Pueden interactuar también de modo sinérgico con plexinas y con RECEPTORES VEGF para formar complejos de receptor, con distintas afinidades y especificidades. La especificidad de unión de la neuropilina está determinada específicamente por CUB y por dominios similares a factores de coagulación en la porción extracelular de la molécula, mientras que para la TRANSDUCCIÓN DE SEÑALES es esencial un dominio MAM.
Descriptor Portuguese: Neuropilinas
Descriptor French: Neuropilines
Entry term(s): Neuropilin
Tree number(s): D12.776.543.750.590
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039921
Scope note: Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Nerve Tissue Proteins (1998-2002)
Public MeSH Note: 2003; NEUROPILIN was indexed under NERVE TISSUE PROTEINS 1998-2002
History Note: 2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002
DeCS ID: 37475
Unique ID: D039921
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/05/31
Neuropilins - Preferred
Concept UI M0191838
Scope note Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
Preferred term Neuropilins
Entry term(s) Neuropilin



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