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Descriptor English: Ofloxacin
Descriptor Spanish: Ofloxacino
Descriptor ofloxacin
Scope note: Fluoroquinolona sintética, un agente antibacteriano que inhibe la actividad de superenrollamiento de la ADN GIRASA bacteriana, impidiendo la REPLICACIÓN DEL ADN.
Descriptor Portuguese: Ofloxacino
Descriptor French: Ofloxacine
Entry term(s): DL 8280
DL-8280
DL8280
DR 3355
DR-3355
DR3355
Hoe 280
Hoe-280
Hoe280
ORF 28489
ORF-28489
ORF28489
Ofloxacin Hydrochloride
Ofloxacine
Ru 43280
Ru-43280
Ru43280
Tarivid
Tree number(s): D03.633.100.810.835.322.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015242
Scope note: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Infective Agents, Urinary
Anti-Bacterial Agents
Topoisomerase II Inhibitors
Cytochrome P-450 CYP1A2 Inhibitors
Registry Number: A4P49JAZ9H
CAS Type 1 Name: (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid
Previous Indexing: Anti-Infective Agents (1981-1988)
Anti-Infective Agents, Urinary (1981-1988)
Oxazines (1981-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 23786
Unique ID: D015242
NLM Classification: QV 250
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/16
Revision Date: 2016/05/31
Ofloxacin - Preferred
Concept UI M0023430
Scope note A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Preferred term Ofloxacin
Entry term(s) Ofloxacine
Tarivid - Narrower
Concept UI M0023432
Preferred term Tarivid
ORF-28489 - Narrower
Concept UI M0333652
Preferred term ORF-28489
Entry term(s) ORF 28489
ORF28489
DR-3355 - Narrower
Concept UI M0353373
Preferred term DR-3355
Entry term(s) DR 3355
DR3355
Hoe-280 - Narrower
Concept UI M0333651
Preferred term Hoe-280
Entry term(s) Hoe 280
Hoe280
Ofloxacin Hydrochloride - Narrower
Concept UI M0329515
Preferred term Ofloxacin Hydrochloride
Ru-43280 - Narrower
Concept UI M0333653
Preferred term Ru-43280
Entry term(s) Ru 43280
Ru43280
DL-8280 - Narrower
Concept UI M0333650
Preferred term DL-8280
Entry term(s) DL 8280
DL8280



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