Pesquisa sobre: P-TYPE ATPASES 
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Descritor Inglês:   P-type ATPases 
Descritor Espanhol:   ATPasas Tipo P 
Descritor Português:   ATPases do Tipo-P 
Sinônimos Inglês:   ATPases, E1-E2
ATPases, P-type
ATPases, Phosphorylation-type
Adenosine Triphosphatases, P-type
Adenosine Triphosphatases, Phosphorylation-type
E1 E2 ATPases
E1-E2 ATPases
P type ATPases
P type Adenosine Triphosphatases
P-type Adenosine Triphosphatases
Phosphorylation type ATPases
Phosphorylation type Adenosine Triphosphatases
Phosphorylation-type ATPases
Phosphorylation-type Adenosine Triphosphatases
Triphosphatases, P-type Adenosine
Triphosphatases, Phosphorylation-type Adenosine  
Categoria:   D08.811.
Definição Inglês:   A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56997 
Identificador Único:   D000073779 

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