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Descriptor English: Pentostatin
Descriptor Spanish: Pentostatina
Descriptor pentostatina
Entry term(s) 2'-desoxicoformicina
CI 825
CI-825
CI825
NSC 218321
NSC-218321
NSC218321
Nipent
desoxicoformicina
Scope note: Potente inhibidor de la ADENOSINA DESAMINASA. Este fármaco induce APOPTOSIS de LINFOCITOS y se utiliza para tratamiento de muchas enfermedades malignas linfoproliferativas, particularmente la LEUCEMIA DE CÉLULAS PILOSAS. También crea sinergia con algunos otros agentes antineoplásicos y posee actividad inmunosupresora.
Descriptor Portuguese: Pentostatina
Descriptor French: Pentostatine
Entry term(s): 2' Deoxycoformycin
2'-Deoxycoformycin
CI 825
CI-825
CI825
Co-Vidarabine
Deoxycoformycin
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
NSC 218321
NSC-218321
NSC218321
Nipent
Tree number(s): D03.383.742.680.350.200.700
D13.570.230.677
D13.570.685.350.200.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015649
Scope note: A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Adenosine Deaminase Inhibitors
Registry Number: 395575MZO7
CAS Type 1 Name: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
Previous Indexing: Azepines (1966-1978)
Coformycin/analogs & derivatives (1979-1989)
Deoxyribonucleosides (1971-1978)
Public MeSH Note: 1997 (1990); CO-VIDARABINE (now PENTOSTATIN) was indexed under VIDARABINE/*analogs & derivatives 1976-97
History Note: 1997 (1990); for CO-VIDARABINE use PENTOSTATIN 1982-1997
DeCS ID: 24830
Unique ID: D015649
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2018/06/13
Pentostatin - Preferred
Concept UI M0023987
Scope note A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Preferred term Pentostatin
Deoxycoformycin - Related but not broader or narrower
Concept UI M000642654
Preferred term Deoxycoformycin
Entry term(s) 2' Deoxycoformycin
2'-Deoxycoformycin
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
NSC-218321 - Narrower
Concept UI M0333703
Preferred term NSC-218321
Entry term(s) NSC 218321
NSC218321
Co-Vidarabine - Related but not broader or narrower
Concept UI M000638634
Preferred term Co-Vidarabine
CI-825 - Narrower
Concept UI M0333704
Preferred term CI-825
Entry term(s) CI 825
CI825
Nipent - Narrower
Concept UI M0474210
Preferred term Nipent



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