Pesquisa sobre: PHENYTOIN 
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Descritor Inglês:   Phenytoin 
Descritor Espanhol:   Fenitoína 
Descritor Português:   Fenitoína 
Sinônimos Inglês:   5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Antisacer
Difenin
Dihydan
Dilantin
Diphenylhydantoin
Diphenylhydantoinate, Sodium
Epamin
Epanutin
Fenitoin
Hydantol
Phenytoin Sodium
Sodium Diphenylhydantoinate  
Categoria:   D03.383.129.308.432.555.730
Definição Inglês:   An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. 
Ação Farmacológica:   Anticonvulsants
Voltage-Gated Sodium Channel Blockers
Cytochrome P-450 CYP1A2 Inducers
 
Nota Histórica Inglês:   78; was DIPHENYLHYDANTOIN 1963-77 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Número do Registro:   10867 
Identificador Único:   D010672 

Ocorrência na BVS:
 

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