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Descriptor English: Protamines
Descriptor Spanish: Protaminas
Descriptor protaminas
Entry term(s) protamina
sulfato de protamina
Scope note: Grupo de proteínas simples que por hidrólisis producen aminoácidos básicos y que se encuentran combinadas con los ácidos nucleicos en la esperma de peces. Las protaminas contienen muy pocos tipos de aminoácidos. El sulfato de protamina se combina con la heparina para formar un complejo estable inactivo y se utiliza en el tratamiento de sobredosis de heparina para neutralizar su acción anticoagulante. (Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Descriptor Portuguese: Protaminas
Descriptor French: Protamine
Entry term(s): Chloride, Protamine
Protamine
Protamine Chloride
Protamine Sulfate
Sulfate, Protamine
Tree number(s): D12.776.660.750
D12.776.664.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011479
Scope note: A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Annotation: heparin antag
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Heparin Antagonists
DeCS ID: 23432
Unique ID: D011479
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Protamines - Preferred
Concept UI M0017844
Scope note A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Preferred term Protamines
Entry term(s) Protamine
Protamine Sulfate - Narrower
Concept UI M0017843
Preferred term Protamine Sulfate
Entry term(s) Sulfate, Protamine
Protamine Chloride - Narrower
Concept UI M0017842
Preferred term Protamine Chloride
Entry term(s) Chloride, Protamine



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