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Descritor Inglês:   Proto-Oncogene Proteins c-bcr 
Descritor Espanhol:   Proteínas Proto-Oncogénicas c-bcr 
Descritor Português:   Proteínas Proto-Oncogênicas c-bcr 
Sinônimos Inglês:   Breakpoint Cluster Region Protein
Proto Oncogene Protein bcr
Proto Oncogene Protein c bcr
Proto Oncogene Proteins c bcr
Proto-Oncogene Protein bcr
Proto-Oncogene Protein c-bcr
Proto-Oncogene Proteins, bcr
Proto-Oncogene Proteins, c-bcr
bcr Proto Oncogene Proteins
bcr Proto-Oncogene Proteins
c bcr Proteins
c bcr Proto Oncogene Proteins
c-bcr Proteins
c-bcr Proto-Oncogene Proteins
c-bcr, Proto-Oncogene Protein
c-bcr, Proto-Oncogene Proteins  
Categoria:   D08.811.913.696.620.682.700.759
Definição Inglês:   A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients. 
Nota Histórica Inglês:   2006(1988) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   50725 
Identificador Único:   D051562 

Ocorrência na BVS: