Pesquisa sobre: STAT TRANSCRIPTION FACTORS 
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Descritor Inglês:   STAT Transcription Factors 
Descritor Espanhol:   Factores de Transcripción STAT 
Descritor Português:   Fatores de Transcrição STAT 
Sinônimos Inglês:   STAT (Signal Transducers and Activators of Transcription) Proteins
Transcription Factors, STAT  
Categoria:   D12.644.360.024.342
D12.776.157.057.186
D12.776.476.024.430
D12.776.930.840
Definição Inglês:   A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT. 
Nota de Indexação Inglês:   general; prefer specifics
Nota Histórica Inglês:   2006 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   50795 
Identificador Único:   D050791 

Ocorrência na BVS:
 
LILACS    
MEDLINE    
BBO    
IBECS    

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