Pesquisa sobre: ZIDOVUDINE 
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Descritor Inglês:   Zidovudine 
Descritor Espanhol:   Zidovudina 
Descritor Português:   Zidovudina 
Sinônimos Inglês:   3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
AZT (Antiviral)
AZT Antiviral
AZT, Antiviral
Antiviral AZT
BW A509U
BWA 509U
Categoria:   D03.383.742.680.705.950
Definição Inglês:   A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. 
Ação Farmacológica:   Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Nota Histórica Inglês:   89 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Número do Registro:   23867 
Identificador Único:   D015215 

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