Pesquisa sobre: ALPHA-MANNOSIDASE 
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Descritor Inglês:   alpha-Mannosidase 
Descritor Espanhol:   alfa-Manosidasa 
Descritor Português:   alfa-Manosidase 
Sinônimos Inglês:   LAMAN
Lysosomal alpha Mannosidase
Lysosomal alpha-Mannosidase
Mannohydrolase, alpha-D-Mannoside
Mannosidase B, alpha
Neutral alpha Mannosidase
Neutral alpha-Mannosidase
alpha D Mannosidase
alpha D Mannoside Mannohydrolase
alpha Mannosidase
alpha Mannosidase B
alpha-D-Mannosidase
alpha-D-Mannoside Mannohydrolase
alpha-Mannosidase, Lysosomal
alpha-Mannosidase, Neutral  
Categoria:   D08.811.277.450.625.500
Definição Inglês:   An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS. 
Nota de Indexação Inglês:   /DEFIC: consider also ALPHA-MANNOSIDOSIS
Relacionados Inglês:   alpha-Mannosidosis
 
Nota Histórica Inglês:   2004; use ALPHA-MANNOSIDASE (NM) 1980-2003 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   38163 
Identificador Único:   D043323 

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