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Descriptor English: Fibromodulin
Descriptor Spanish: Fibromodulina
Descriptor fibromodulina
Entry term(s) proteína FMOD
Scope note: Pequeño proteoglucano rico en leucina que contiene cadenas de 4 QUERATÁN SULFATO entre las regiones de repetición de leucina. Interacciona con las fibras de COLÁGENO DE TIPO I y COLÁGENO DE TIPO II y puede actuar controlando la velocidad de ensamblaje de la MATRIZ EXTRACELULAR. También secuestra el FACTOR DE CRECIMIENTO TRANSFORMADOR BETA en la matriz extracelular.
Descriptor Portuguese: Fibromodulina
Descriptor French: Fibromoduline
Entry term(s): FMOD Protein
Tree number(s): D09.698.735.700.813
D12.776.395.650.875.625
D12.776.860.300.806.813
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071235
Scope note: A small leucine-rich proteoglycan that contains 4 KERATAN SULFATE chains within the leucine repeat region. It interacts with COLLAGEN TYPE I and COLLAGEN TYPE II fibrils and may function to control the rate of EXTRACELLULAR MATRIX assembly. It also sequesters TRANSFORMING GROWTH FACTOR BETA in the extracellular matrix.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 126468-95-9
Public MeSH Note: 2017; FIBROMODULIN was indexed under PROTEOGLYCANS and EXTRACELLULAR MATRIX PROTEINS 2004-2016, and under CARRIER PROTEINS 1989-2004
History Note: 2017 (1989)
DeCS ID: 56523
Unique ID: D000071235
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Fibromodulin - Preferred
Concept UI M0171379
Scope note A small leucine-rich proteoglycan that contains 4 KERATAN SULFATE chains within the leucine repeat region. It interacts with COLLAGEN TYPE I and COLLAGEN TYPE II fibrils and may function to control the rate of EXTRACELLULAR MATRIX assembly. It also sequesters TRANSFORMING GROWTH FACTOR BETA in the extracellular matrix.
Preferred term Fibromodulin
Entry term(s) FMOD Protein



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