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Descriptor English: Granzymes
Descriptor Spanish: Granzimas
Descriptor granzimas
Scope note: Familia de serina endopeptidasas que se encuentran en los GRÁNULOS SECRETORES de los LEUCOCITOS como los LINFOCITOS T CITOTÓXICOS y CÉLULAS ASESINAS NATURALES. Cuando se segregan al espacio intercelular las granzimas actúan eliminando las células huésped transformadas e infectadas por virus.
Descriptor Portuguese: Granzimas
Descriptor French: Granzymes
Entry term(s): Cytotoxic Serine Protease B
Cytotoxic T Lymphocyte Associated 1 Protein
Cytotoxic T Lymphocyte Proteinase 1
Cytotoxic T-Lymphocyte Associated 1 Protein
Cytotoxic T-Lymphocyte Proteinase 1
Fragmentin 2
Granzyme
Granzyme 3
Granzyme A
Granzyme B
Granzyme C
Granzyme K
Granzyme Like Protein III
Granzyme M
Granzyme-3
Granzyme-Like Protein III
Hanukah Factor
NK Tryptase 2
NK-Tryptase-2
Natural Killer Cell Granule Tryptase 2
Natural Killer Cell Granule Tryptase-2
Tree number(s): D08.811.277.656.300.760.397
D08.811.277.656.959.350.397
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053804
Scope note: A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Cytotoxins
Registry Number: EC 3.4.21.-
Public MeSH Note: 2007; GRANZYME A was indexed under SERINE ENDOPEPTIDASES 1986-2006; GRANZYME B was indexed under SERINE ENDOPEPTIDASES 1989-2006; GRANZYME C was indexed under SERINE ENDOPEPTIDASES 1988-2006; GRANZYME M was indexed under SERINE ENDOPEPTIDASES 1999-2006; GRANZYME-LIKE PROTEIN III was indexed under SERINE ENDOPEPTIDASES 1994-2006; GRANZYME K was indexed under SERINE ENDOPEPTIDASES 2003-2006
History Note: 2007(1986)
DeCS ID: 52244
Unique ID: D053804
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2009/07/06
Granzymes - Preferred
Concept UI M0496635
Scope note A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
Preferred term Granzymes
Entry term(s) Granzyme
Granzyme M - Narrower
Concept UI M0352923
Preferred term Granzyme M
Granzyme C - Narrower
Concept UI M0153862
Preferred term Granzyme C
Granzyme K - Narrower
Concept UI M0210456
Preferred term Granzyme K
Entry term(s) Granzyme 3
Granzyme-3
NK Tryptase 2
NK-Tryptase-2
Natural Killer Cell Granule Tryptase 2
Natural Killer Cell Granule Tryptase-2
Granzyme A - Narrower
Concept UI M0456799
Preferred term Granzyme A
Entry term(s) Cytotoxic T Lymphocyte Proteinase 1
Cytotoxic T-Lymphocyte Proteinase 1
Hanukah Factor
Granzyme B - Narrower
Concept UI M0168804
Preferred term Granzyme B
Entry term(s) Cytotoxic Serine Protease B
Cytotoxic T Lymphocyte Associated 1 Protein
Cytotoxic T-Lymphocyte Associated 1 Protein
Fragmentin 2
Granzyme Like Protein III
Granzyme-Like Protein III



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