Search
Descriptor English: Pyrin
Descriptor Spanish: Pirina
Descriptor pirina
Entry term(s) marenostrina
proteína MEFV
proteína TRIM20
proteína de fiebre mediterránea
proteína de la fiebre mediterránea
Scope note: Proteína de motivos tripartitos que consta de un dominio de pirina N-terminal, una región central en hélice superenrollada y DEDOS DE ZINC de tipo caja B y regiones C-terminales que median en la homotrimerización e interacciones con otras proteínas (DOMINIO B30.2-SPRY). Se expresa principalmente en los GRANULOCITOS maduros y se asocia al citoesqueleto en el área perinuclear y en los AUTOFAGOSOMAS, donde coordina el ensamblaje de las PROTEÍNAS RELACIONADAS CON LA AUTOFAGIA y la degradación de los componentes de los INFLAMASOMAS. La proteína de la fiebre mediterránea participa en la INMUNIDAD INNATA y la INFLAMACIÓN. Las mutaciones en el gen MEFV se asocian a la FIEBRE MEDITERRÁNEA FAMILIAR.
Descriptor Portuguese: Pirina
Descriptor French: Pyrine
Entry term(s): MEFV Protein
Marenostrin
Mediterranean Fever Protein
TRIM20 Protein
Tree number(s): D12.776.220.909
D12.776.934.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071198
Scope note: A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; PYRIN was indexed under PROTEINS 1997; and under CYTOSKELETAL PROTEINS 1998-2016
History Note: 2017 (1997)
Related: Pyrin Domain MeSH
DeCS ID: 56595
Unique ID: D000071198
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05
Pyrin - Preferred
Concept UI M0281114
Scope note A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
Preferred term Pyrin
Entry term(s) MEFV Protein
Marenostrin
Mediterranean Fever Protein
TRIM20 Protein



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey