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Descriptor English: Nimustine
Descriptor Spanish: Nimustina
Descriptor nimustina
Entry term(s) ACNU
Scope note: Agente antineoplásico específicamente eficaz contra tumores malignos del cerebro. La resistencia que las células tumorales encefálicas adquieren frente a la eficacia inicial de este fármaco puede ser parcialmente superada con el empleo simultáneo de agentes modificadores de la membrana, tales como reserpina, antagonistas del calcio como la nicardipina o el verapamilo, e el inhibidor de la calmodulina, trifluoperazina. Se ha utilizado también este fármaco en combinación con otros agentes antineoplásicos o con la radioterapia para el tratamiento de varias neoplasias.
Descriptor Portuguese: Nimustina
Descriptor French: Nimustine
Entry term(s): ACNU
NSC 245382
Tree number(s): D02.065.950.594.550
D02.654.692.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015376
Scope note: Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Registry Number: 0S726V972K
CAS Type 1 Name: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-
Previous Indexing: Antineoplastic Agents (1975-1988)
Nitrosourea Compounds (1975-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 24416
Unique ID: D015376
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/06/03
Revision Date: 2016/06/28
Nimustine - Preferred
Concept UI M0023686
Scope note Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Preferred term Nimustine
Entry term(s) ACNU
NSC 245382 - Narrower
Concept UI M0352097
Preferred term NSC 245382



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