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Descriptor English: Baclofen
Descriptor Spanish: Baclofeno
Descriptor baclofeno
Entry term(s) baclofen
clorofenil GABA
Scope note: Derivado del ÁCIDO GAMMA-AMINOBUTÍRICO que es agonista específico de los RECEPTORES DE GABA-B. Se emplea en el tratamiento de la ESPASTICIDAD MUSCULAR, especialmente la debida a LESIONES DE LA MÉDULA ESPINAL. Sus efectos terapéuticos son consecuencia de acciones en la médula espinal y supraespinal, generalmente la reducción de la transmisión excitatoria.
Descriptor Portuguese: Baclofeno
Descriptor French: Baclofène
Entry term(s): AWD, Baclofen
Apo Baclofen
Apo-Baclofen
ApoBaclofen
Atrofen
Ba-34,647
Ba-34647
Ba34,647
Ba34647
Baclofen AWD
Baclofène Irex
Baclofène-Irex
BaclofèneIrex
Baclophen
Baclospas
CIBA-34,647-BA
CIBA34,647BA
Chlorophenyl GABA
Clofen
GABA, Chlorophenyl
Gen Baclofen
Gen-Baclofen
GenBaclofen
Genpharm
Lebic
Lioresal
Liorésal
Nu Baclo
Nu-Baclo
NuBaclo
PCP-GABA
PMS Baclofen
PMS-Baclofen
PMSBaclofen
beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Tree number(s): D02.241.081.114.500.350.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001418
Scope note: A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Muscle Relaxants, Central
GABA-B Receptor Agonists
Registry Number: H789N3FKE8
CAS Type 1 Name: Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-
Previous Indexing: Aminobutyric Acids (1972-1974)
Chlorobenzenes (1974)
Public MeSH Note: 80; was see under AMINOBUTYRIC ACIDS 1975-79
History Note: 80(75); was see under AMINOBUTYRIC ACIDS 1975-79
DeCS ID: 1442
Unique ID: D001418
NLM Classification: QV 140
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/07/05
Baclofen - Preferred
Concept UI M0002117
Scope note A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
Preferred term Baclofen
Entry term(s) Baclophen
Chlorophenyl GABA
GABA, Chlorophenyl
PCP-GABA
beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Clofen - Narrower
Concept UI M0454551
Preferred term Clofen
Gen-Baclofen - Narrower
Concept UI M0454550
Preferred term Gen-Baclofen
Entry term(s) Gen Baclofen
GenBaclofen
Genpharm
Apo-Baclofen - Narrower
Concept UI M0454555
Preferred term Apo-Baclofen
Entry term(s) Apo Baclofen
ApoBaclofen
Atrofen - Narrower
Concept UI M0454554
Preferred term Atrofen
Baclofène-Irex - Narrower
Concept UI M0454553
Preferred term Baclofène-Irex
Entry term(s) Baclofène Irex
BaclofèneIrex
Baclofen AWD - Narrower
Concept UI M0454556
Preferred term Baclofen AWD
Entry term(s) AWD, Baclofen
Lebic - Narrower
Concept UI M0454549
Preferred term Lebic
Lioresal - Narrower
Concept UI M0002118
Preferred term Lioresal
Entry term(s) Liorésal
Nu-Baclo - Narrower
Concept UI M0454547
Preferred term Nu-Baclo
Entry term(s) Nu Baclo
NuBaclo
PMS-Baclofen - Narrower
Concept UI M0454548
Preferred term PMS-Baclofen
Entry term(s) PMS Baclofen
PMSBaclofen
Baclospas - Narrower
Concept UI M0454552
Preferred term Baclospas
Ba-34,647 - Narrower
Concept UI M0351459
Preferred term Ba-34,647
Entry term(s) Ba-34647
Ba34,647
Ba34647
CIBA-34,647-BA
CIBA34,647BA



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