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Descriptor English: Cantharidin
Descriptor Spanish: Cantaridina
Descriptor cantaridina
Entry term(s) cantáridas
Scope note: Compuesto tóxico, aislado a partir de la Mosca española, escarabajo vesicatorio o cantárida (Lytta (Cantharis) vesicatoria) y de otros insectos. Es un potente y específico inhibidor de las proteinfosfatasas 1 (PP1) y 2A (PP2A). Este compuesto puede producir intensa inflamación cutánea y, si se ingiere, es extremadamente toxico.
Descriptor Portuguese: Cantaridina
Descriptor French: Cantharidine
Entry term(s): Cantharides
Cantharidine
Tree number(s): D03.633.100.127.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002193
Scope note: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AN analysis
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
Pharm Action: Enzyme Inhibitors
Irritants
Registry Number: IGL471WQ8P
CAS Type 1 Name: 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aalpha,4beta,7beta,7aalpha)-
Public MeSH Note: 79; was CANTHARIDES 1963-78
Online Note: use CANTHARIDIN to search CANTHARIDES 1966-78
History Note: 79; was CANTHARIDES 1963-78
DeCS ID: 2225
Unique ID: D002193
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1979/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/27
Cantharidin - Preferred
Concept UI M0003285
Scope note A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
Preferred term Cantharidin
Entry term(s) Cantharidine
Cantharides - Related but not broader or narrower
Concept UI M0003284
Preferred term Cantharides



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