Search on: COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS 
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Descriptor English:   Colorectal Neoplasms, Hereditary Nonpolyposis 
Descriptor Spanish:   Neoplasias Colorrectales Hereditarias sin Poliposis 
Descriptor Portuguese:   Neoplasias Colorretais Hereditárias sem Polipose 
Synonyms English:   Colon Cancer, Familial Nonpolyposis
Colorectal Cancer Hereditary Nonpolyposis
Familial Nonpolyposis Colon Cancer
Hereditary Nonpolyposis Colon Cancer
Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Neoplasms
Lynch Cancer Family Syndrome I
Lynch Syndrome
Lynch Syndrome I
Syndrome, Lynch  
Tree Number:   C04.588.274.476.411.307.190
C04.700.250
C06.301.371.411.307.190
C06.405.249.411.307.190
C06.405.469.158.356.190
C06.405.469.491.307.190
C16.320.700.250
C18.452.284.255
Definition English:   A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer. 
History Note English:   87 
Allowable Qualifiers English:  
BS blood supply BL blood
CF cerebrospinal fluid CI chemically induced
CH chemistry CL classification
CO complications DI diagnosis
DG diagnostic imaging DH diet therapy
DT drug therapy EC economics
EM embryology EN enzymology
EP epidemiology EH ethnology
ET etiology GE genetics
HI history IM immunology
ME metabolism MI microbiology
MO mortality NU nursing
PS parasitology PA pathology
PP physiopathology PC prevention & control
PX psychology RT radiotherapy
RH rehabilitation SC secondary
SU surgery TH therapy
UL ultrastructure UR urine
VE veterinary VI virology
Record Number:   24009 
Unique Identifier:   D003123 

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