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Descriptor English: Didanosine
Descriptor Spanish: Didanosina
Descriptor didanosina
Entry term(s) 2',3'-didesoxinosina
ddI (antiviral)
didesoxinosina
Scope note: Didesoxinucleósido en el que el grupo 3'-hidroxilo de la molécula de azúcar ha sido reemplazado por un hidrógeno. Esta modificación impide la formación de los enlaces fosfodiéster necesarios para formar las cadenas de ácido nucleico. La dinadosina es un potente inhibidor de la replicación del VIH, y actúa como terminal de la cadena del ADN viral al unirse a la transcriptasa inversa; el ddi es entonces metabolizado a trifosfato de didesoxiadenosina, que es su metabolito putativo activo.
Descriptor Portuguese: Didanosina
Descriptor French: Didéoxyinosine
Entry term(s): 2',3' Dideoxyinosine
2',3'-Dideoxyinosine
Dideoxyinosine
NSC 612049
NSC-612049
NSC612049
Videx
ddI (Antiviral)
Tree number(s): D03.633.100.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016049
Scope note: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Registry Number: K3GDH6OH08
CAS Type 1 Name: Inosine, 2',3'-dideoxy-
Previous Indexing: Dideoxynucleosides (1989)
Inosine/analogs & derivatives (1987-1989)
Public MeSH Note: 92; was DIDEOXYINOSINE 1990-91
Online Note: use DIDANOSINE to search DIDEOXYINOSINE 1990-91
History Note: 92; was DIDEOXYINOSINE 1990-91
DeCS ID: 30328
Unique ID: D016049
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2017/05/24
Didanosine - Preferred
Concept UI M0024535
Scope note A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Preferred term Didanosine
Entry term(s) 2',3' Dideoxyinosine
2',3'-Dideoxyinosine
Dideoxyinosine
ddI (Antiviral)
Videx - Narrower
Concept UI M0024536
Preferred term Videx
NSC-612049 - Narrower
Concept UI M0328965
Preferred term NSC-612049
Entry term(s) NSC 612049
NSC612049



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