Search on: FACTOR XII 
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Descriptor English:   Factor XII 
Descriptor Spanish:   Factor XII 
Descriptor Portuguese:   Fator XII 
Synonyms English:   Coagulation Factor XII
Factor 12
Factor Twelve
Hageman Factor  
Tree Number:   D12.776.124.125.450
D23.119.450
Definition English:   Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III. 
Entry Combination - descr/qualif English:   Factor XII/deficiency use Factor XII Deficiency
 
See Related English:   Coagulants
Hereditary Angioedema Type III
 
History Note English:   66(64) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   22175 
Unique Identifier:   D005174 

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