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Descriptor English: Gabexate
Descriptor Spanish: Gabexato
Descriptor gabexato
Scope note: Inhibidor de la serina proteinasa utilizado terapéuticamente en el tratamiento de la pancreatitis, coagulación intravascular diseminada (CID) y como anticoagulante regional para hemodiálisis. El fármaco inhibe los efectos hidrolíticos de la trombina, plasmina y calicreína pero no de la quimotripsina y aprotinina.
Descriptor Portuguese: Gabexato
Descriptor French: Gabexate
Entry term(s): Foy
Gabexate Mesilate
Gabexate Mesylate
Gabexate Methanesulfonate
Gabexate Monomethanesulfonate
Gabexate Monomethanesulfonate, 14C Labeled Cpd
Gabexate Monomethanesulfonate, 14C-Labeled Cpd
Mesilate, Gabexate
Mesylate, Gabexate
Methanesulfonate, Gabexate
Monomethanesulfonate, Gabexate
Tree number(s): D02.078.370.380
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016670
Scope note: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticoagulants
Serine Proteinase Inhibitors
Registry Number: 4V7M9137X9
CAS Type 1 Name: Benzoic acid, 4-((6-((aminoiminomethyl)amino)-1-oxohexyl)oxy)-, ethyl ester
Previous Indexing: Anticoagulants (1966-1991)
Guanidines (1966-1991)
Protease Inhibitors (1979-1989)
Serine Proteinase Inhibitors (1990-1991)
Public MeSH Note: 92; GABEXATE was indexed under GUANIDINES 1976-91
Online Note: use GABEXATE (NM) to search GABEXATE 1979-91
History Note: 92; was GABEXATE (NM) 1976-91
DeCS ID: 30093
Unique ID: D016670
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/25
Revision Date: 2013/07/08
Gabexate - Preferred
Concept UI M0025401
Scope note A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Preferred term Gabexate
Gabexate Monomethanesulfonate, 14C-Labeled Cpd - Narrower
Concept UI M0329388
Preferred term Gabexate Monomethanesulfonate, 14C-Labeled Cpd
Entry term(s) Gabexate Monomethanesulfonate, 14C Labeled Cpd
Gabexate Monomethanesulfonate - Narrower
Concept UI M0329389
Preferred term Gabexate Monomethanesulfonate
Entry term(s) Monomethanesulfonate, Gabexate
Foy - Narrower
Concept UI M0025402
Preferred term Foy
Gabexate Methanesulfonate - Narrower
Concept UI M0329387
Preferred term Gabexate Methanesulfonate
Entry term(s) Gabexate Mesilate
Gabexate Mesylate
Mesilate, Gabexate
Mesylate, Gabexate
Methanesulfonate, Gabexate



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