Search on: HBGF-2 
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Descriptor English:   Fibroblast Growth Factor 2 
Descriptor Spanish:   Factor 2 de Crecimiento de Fibroblastos 
Descriptor Portuguese:   Fator 2 de Crescimento de Fibroblastos 
Synonyms English:   Cartilage-Derived Growth Factor
Class II Heparin-Binding Growth Factor
Fibroblast Growth Factor-2
Heparin-Binding Growth Factor Class II
Prostate Epithelial Cell Growth Factor
Cartilage Derived Growth Factor
Basic Fibroblast Growth Factor
Fibroblast Growth Factor, Basic
Tree Number:   D12.644.276.624.120
Definition English:   A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1). 
History Note English:   2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   28936 
Unique Identifier:   D016222 

Occurrence in VHL: