Search on: HEAVY CHAIN DISEASE, IGA TYPE 
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Descriptor English:   Immunoproliferative Small Intestinal Disease 
Descriptor Spanish:   Enfermedad Inmunoproliferativa del Intestino Delgado 
Descriptor Portuguese:   Doença Imunoproliferativa do Intestino Delgado 
Synonyms English:   Disease, alpha-Chain
Diseases, alpha-Chain
Heavy Chain Disease, IgA Type
IPSID
Lymphoma, Mediterranean
Mediterranean Lymphoma
alpha Chain Disease
alpha-Chain Disease
alpha-Chain Diseases  
Tree Number:   C04.557.386.390
C06.301.371.411.512
C06.405.249.411.512
C06.405.469.491.505
C15.378.147.780.490.512
C15.604.515.435.512
C20.683.515.512
C20.683.780.490.512
Definition English:   A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA. 
History Note English:   87 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   19205 
Unique Identifier:   D007161 

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