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Descriptor English:   G(M3) Ganglioside 
Descriptor Spanish:   Gangliósido G(M3) 
Descriptor Portuguese:   Gangliosídeo G(M3) 
Synonyms English:   GM3, Ganglioside
Ganglioside GM3
Hematoside
II3NeuAcLacCer
Lactosylceramide, Sialyl
Sialyl Lactosylceramide
Sialyllactosylceramide  
Tree Number:   D09.400.410.420.025.475.510
D10.390.470.025.475.510
D10.570.877.360.025.475.510
Definition English:   A ganglioside present in abnormally large amounts in the brain and liver due to a deficient biosynthetic enzyme, G(M3):UDP-N-acetylgalactosaminyltransferase. Deficiency of this enzyme prevents the formation of G(M2) ganglioside from G(M3) ganglioside and is the cause of an anabolic sphingolipidosis. 
Indexing Annotation English:   G(M3) gangliosidosis: coord NIM with GANGLIOSIDOSIS (IM)
History Note English:   91(77); was see under GANGLIOSIDES 1977-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   5817 
Unique Identifier:   D005679 

Occurrence in VHL:
 
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