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Descriptor English:   Hemicholinium 3 
Descriptor Spanish:   Hemicolinio 3 
Descriptor Portuguese:   Hemicolínio 3 
Synonyms English:   Hemicholinium  
Tree Number:   D02.092.877.435
Definition English:   A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments. 
Pharmacological Action:   Neurotransmitter Uptake Inhibitors
Cholinergic Agents
History Note English:   72 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   6575 
Unique Identifier:   D006426 

Occurrence in VHL: