Descriptors Found: 1
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 1 / 1 DeCS     
Descriptor English:   Hemoglobin, Sickle 
Descriptor Spanish:   Hemoglobina Falciforme 
Descriptor Portuguese:   Hemoglobina Falciforme 
Synonyms English:   Deoxygenated Sickle Hemoglobin
Deoxyhemoglobin S
Hemoglobin S
Hemoglobin SS
Hemoglobin, Deoxygenated Sickle
SS, Hemoglobin
Sickle Hemoglobin
Sickle Hemoglobin, Deoxygenated  
Tree Number:   D12.776.124.400.463.588
Definition English:   An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia. 
Indexing Annotation English:   /urine: coord IM with HEMOGLOBINURIA (IM); hemoglobin S disease = ANEMIA, SICKLE CELL
History Note English:   77(75); was HEMOGLOBIN S 1973-74 (Prov) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   22197 
Unique Identifier:   D006451 

Occurrence in VHL: