Search on: HEMOGLOBINURIA, PAROXYSMAL 
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Descriptor English:   Hemoglobinuria, Paroxysmal 
Descriptor Spanish:   Hemoglobinuria Paroxística 
Descriptor Portuguese:   Hemoglobinúria Paroxística 
Synonyms English:   Cold Paroxysmal Hemoglobinuria
Hemoglobinuria, Cold Paroxysmal
Hemoglobinuria, Nocturnal Paroxysmal
Hemoglobinuria, Paroxysmal Cold
Hemoglobinuria, Paroxysmal Nocturnal
Marchiafava Micheli Syndrome
Marchiafava-Micheli Syndrome
Nocturnal Paroxysmal Hemoglobinuria
Paroxysmal Cold Hemoglobinuria
Paroxysmal Hemoglobinuria
Paroxysmal Hemoglobinuria, Cold
Paroxysmal Hemoglobinuria, Nocturnal
Paroxysmal Nocturnal Hemoglobinuria
Syndrome, Marchiafava-Micheli  
Tree Number:   C15.378.071.141.560
C15.378.190.625.460
Definition English:   A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins. 
History Note English:   78; was MARCHIAFAVA-MICHELI SYNDROME 1963-77 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   6607 
Unique Identifier:   D006457 

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