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Descriptor English: Hepcidins
Descriptor Spanish: Hepcidinas
Descriptor hepcidinas
Scope note: Formas de hepcidina, un péptido catiónico anfipático sintetizado en el hígado como prepropéptido, que es primero procesado a prohepcidina y luego a las formas biológicamente activas de hepcidina incluyendo en humanos los péptidos de 20-, 22-, y 25-aminoácidos. La hepcidina actúa como regulador homeostático del metabolismo del hierro y también posee actividad antimicrobiana.
Descriptor Portuguese: Hepcidinas
Descriptor French: Hepcidines
Entry term(s): Antimicrobial Peptide, Liver-Expressed
Hepcidin
Liver Expressed Antimicrobial Peptide
Liver-Expressed Antimicrobial Peptide
Peptide, Liver-Expressed Antimicrobial
Pro Hepcidin
Pro-Hepcidin
Prohepcidin
Tree number(s): D12.776.494.249
D12.776.543.695.054.425
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064451
Scope note: Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Infective Agents
Previous Indexing: Antimicrobial Cationic Peptides (2013)
Public MeSH Note: 2014
History Note: 2014
Related: Anemia MeSH
Hemochromatosis MeSH
DeCS ID: 55332
Unique ID: D064451
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Hepcidins - Preferred
Concept UI M0581933
Scope note Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
Preferred term Hepcidins
Entry term(s) Antimicrobial Peptide, Liver-Expressed
Hepcidin
Liver Expressed Antimicrobial Peptide
Liver-Expressed Antimicrobial Peptide
Peptide, Liver-Expressed Antimicrobial
Prohepcidin - Narrower
Concept UI M0501865
Preferred term Prohepcidin
Entry term(s) Pro Hepcidin
Pro-Hepcidin



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