| Descriptor English: | MAP Kinase Kinase Kinases | ||||||
| Descriptor Spanish: |
Quinasas Quinasa Quinasa PAM
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| Descriptor Portuguese: | MAP Quinase Quinase Quinases | ||||||
| Descriptor French: | MAP Kinase Kinase Kinases | ||||||
| Entry term(s): |
Kinase Kinase, MAPK-ERK Kinase Kinases, MAPK-ERK Kinase, MAP3 Kinase, MAPK-ERK Kinase Kinase, MEK Kinases, MAP Kinase Kinase Kinases, MAP3 Kinases, MAPK-ERK Kinase Kinases, MEK MAP Kinase Kinase Kinase MAP3 Kinase MAP3 Kinases MAPK ERK Kinase Kinase MAPK ERK Kinase Kinases MAPK-ERK Kinase Kinase MAPK-ERK Kinase Kinases MAPKKK MAPKKKs MEK Kinase MEK Kinases MEKK MEKKs Mitogen Activated Protein Kinase Kinase Kinase Mitogen Activated Protein Kinase Kinase Kinases Mitogen-Activated Protein Kinase Kinase Kinase Mitogen-Activated Protein Kinase Kinase Kinases |
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| Tree number(s): |
D08.811.913.696.620.682.700.559 D12.776.476.563.554 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D020930 | ||||||
| Scope note: | Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.25 | ||||||
| Previous Indexing: |
Protein Kinases (1989-1999) Protein-Serine-Threonine Kinases (1993-1999) Protein-Tyrosine Kinase (1989-1999) |
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| Public MeSH Note: | 2000; MAP KINASE KINASE KINASE (now MAP KINASE KINASE KINASES) was indexed under PROTEIN-SERINE-THREONINE KINASES (1992-1999) |
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| History Note: | 2000; use MAP KINASE KINASE KINASE (1992-1999) |
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| Related: |
MAP Kinase Signaling System
MeSH | ||||||
| DeCS ID: | 34448 | ||||||
| Unique ID: | D020930 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2000/01/01 | ||||||
| Date of Entry: | 1999/11/03 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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MAP Kinase Kinase Kinases
- Preferred
MAPK-ERK Kinase Kinases
- Narrower
| Concept UI |
M0328033 |
| Scope note | Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). |
| Preferred term | MAP Kinase Kinase Kinases |
| Entry term(s) |
Kinase, MAP3 Kinases, MAP Kinase Kinase Kinases, MAP3 MAP Kinase Kinase Kinase MAP3 Kinase MAP3 Kinases MAPKKK MAPKKKs Mitogen Activated Protein Kinase Kinase Kinase Mitogen Activated Protein Kinase Kinase Kinases Mitogen-Activated Protein Kinase Kinase Kinase Mitogen-Activated Protein Kinase Kinase Kinases |
| Concept UI |
M0329022 |
| Preferred term | MAPK-ERK Kinase Kinases |
| Entry term(s) |
Kinase Kinase, MAPK-ERK Kinase Kinases, MAPK-ERK Kinase, MAPK-ERK Kinase Kinase, MEK Kinases, MAPK-ERK Kinase Kinases, MEK MAPK ERK Kinase Kinase MAPK ERK Kinase Kinases MAPK-ERK Kinase Kinase MEK Kinase MEK Kinases MEKK MEKKs |
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