| Descriptor English: | Mitogen-Activated Protein Kinase Kinases | ||||||
| Descriptor Spanish: |
Quinasas de Proteína Quinasa Activadas por Mitógenos
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| Descriptor Portuguese: | Quinases de Proteína Quinase Ativadas por Mitógeno | ||||||
| Descriptor French: | Mitogen-Activated Protein Kinase Kinases | ||||||
| Entry term(s): |
Kinase Kinase, Map Kinase Kinases, MAP Kinase, MAP-ERK Kinase, MAPK Kinase, MAPK-ERK Kinase, Map Kinase Kinases, MAP Kinase Kinases, MAPK Kinases, MAPK-ERK MAP ERK Kinase MAP Kinase Kinases MAP-ERK Kinase MAPK ERK Kinase MAPK ERK Kinases MAPK Kinase MAPK Kinases MAPK-ERK Kinase MAPK-ERK Kinases MAPKK MAPKKs MEK MEKs Map Kinase Kinase Mitogen Activated Protein Kinase Kinase Mitogen Activated Protein Kinase Kinases Mitogen-Activated Protein Kinase Kinase |
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| Tree number(s): |
D08.811.913.696.620.682.700.565 D08.811.913.696.620.682.725.200 D12.776.476.563.565 D12.776.476.568.200 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D020929 | ||||||
| Scope note: | A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.12.2 | ||||||
| Previous Indexing: |
Protein Kinases (1989-1999) Protein-Serine-Threonine Kinases (1993-1999) Protein-Tyrosine Kinase (1989-1999) |
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| Public MeSH Note: | 2000; MAP KINASE KINASE and MAPKK (now MITOGEN-ACTIVATED KINASE KINASES) were indexed under PROTEIN KINASES 1992-1999; MAP-ERK KINASE (now MITOGEN-ACTIVATED KINASE KINASES) was indexed under PROTEIN-TYROSINE KINASE 1992-1999 |
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| History Note: | 2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999 |
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| Related: |
MAP Kinase Signaling System
MeSH | ||||||
| DeCS ID: | 34449 | ||||||
| Unique ID: | D020929 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2000/01/01 | ||||||
| Date of Entry: | 1999/11/03 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Mitogen-Activated Protein Kinase Kinases
- Preferred
MAPK-ERK Kinases
- Narrower
| Concept UI |
M0328038 |
| Scope note | A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily. |
| Preferred term | Mitogen-Activated Protein Kinase Kinases |
| Entry term(s) |
Kinase Kinase, Map Kinase Kinases, MAP Kinase, MAPK Kinase, Map Kinase Kinases, MAP Kinase Kinases, MAPK MAP Kinase Kinases MAPK Kinase MAPK Kinases MAPKK MAPKKs Map Kinase Kinase Mitogen Activated Protein Kinase Kinase Mitogen Activated Protein Kinase Kinases Mitogen-Activated Protein Kinase Kinase |
| Concept UI |
M0331456 |
| Scope note | A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily. |
| Scope note | A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily. |
| Preferred term | MAPK-ERK Kinases |
| Entry term(s) |
Kinase, MAP-ERK Kinase, MAPK-ERK Kinases, MAPK-ERK MAP ERK Kinase MAP-ERK Kinase MAPK ERK Kinase MAPK ERK Kinases MAPK-ERK Kinase MEK MEKs |
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