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Descriptor English: Proteasome Endopeptidase Complex
Descriptor Spanish: Complejo de la Endopetidasa Proteasomal
Descriptor complejo de endopeptidasas de los proteasomas
Scope note: Gran complejo con múltiples subunidades que desempeña una función importante en la degradación de la mayoría de las proteínas citosólicas y nucleares de células eucarióticas. Contiene un subcomplejo catalítico de 700 kDa y dos subcomplejos regulatorios de 700 kDa. El complejo digiere proteínas ubiquitinadas y proteínas activadas a través de la antienzima ornitina-descarboxilasa.
Descriptor Portuguese: Complexo de Endopeptidases do Proteassoma
Descriptor French: Proteasome endopeptidase complex
Entry term(s): 20S Proteasome
Complex, Multicatalytic Endopeptidase
Complex, Proteasome Endopeptidase
Endopeptidase Complex, Multicatalytic
Endopeptidase Complex, Proteasome
Ingensin
Macropain
Macroxyproteinase
Multicatalytic Endopeptidase Complex
Multicatalytic Proteinase
Prosome
Proteasome
Proteasome, 20S
Proteinase, Multicatalytic
Tree number(s): D05.500.562.500
D08.811.277.656.918
D08.811.600.730
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D046988
Scope note: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Proteasome Inhibitors
Registry Number: EC 3.4.25.1
Previous Indexing: Cysteine Endopeptidases (1986-2004)
Multienzyme Complexes (1986-2004)
Public MeSH Note: 2005; PROTEASOME ENDOPEPTIDASE COMPLEX was indexed under CYSTEINE ENDOPEPTIDASES & MULTIENZYME COMPLEXES 1986-2004
History Note: 2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004
Related: Ubiquitin-Protein Ligase Complexes MeSH
DeCS ID: 38685
Unique ID: D046988
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2012/07/03
Proteasome Endopeptidase Complex - Preferred
Concept UI M0140424
Scope note A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Preferred term Proteasome Endopeptidase Complex
Entry term(s) 20S Proteasome
Complex, Multicatalytic Endopeptidase
Complex, Proteasome Endopeptidase
Endopeptidase Complex, Multicatalytic
Endopeptidase Complex, Proteasome
Macropain
Macroxyproteinase
Multicatalytic Endopeptidase Complex
Multicatalytic Proteinase
Prosome
Proteasome
Proteasome, 20S
Proteinase, Multicatalytic
Ingensin - Narrower
Concept UI M0140417
Preferred term Ingensin



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