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Descriptor English: Methysergide
Descriptor Spanish: Metisergida
Descriptor metisergida
Entry term(s) dimetilergometrina
metilmetilergonovina
Scope note: Derivado del cornezuelo del centeno, congénere de la DIETILAMIDA DEL ÁCIDO LISÉRGICO. Antagoniza el efecto de la serotonina en los vasos sanguíneos y en la musculatura lisa gastrointestinal, aunque posee pocas de las propiedades de otros alcaloides del cornezuelo. La metisergida se utiliza profilácticamente en la migraña y otras cefaleas vasculares, y como antagonista de la serotonina en el síndrome carcinoide.
Descriptor Portuguese: Metisergida
Descriptor French: Méthysergide
Entry term(s): Deseril
Desril
Dimaleate, Methysergide
Dimethylergometrin
Désernil Sandoz
Désernil-Sandoz
Maleate, Methysergide
Methylmethylergonovine
Methysergide Dimaleate
Methysergide Maleate
Sansert
UML 491
UML-491
UML491
Tree number(s): D03.132.327.287.689
D03.633.400.439.689
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008784
Scope note: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Serotonin Antagonists
Vasoconstrictor Agents
Registry Number: XZA9HY6Z98
CAS Type 1 Name: Ergoline-8-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethyl-, (8beta(S))-
Public MeSH Note: 65; METHYSERGIDE DERIVATIVES was see under METHYSERGIDE 1975-77; was see under ERGOLINES 1969-74
Online Note: use METHYSERGIDE/analogs & derivatives to search METHYSERGIDE DERIVATIVES 1975-77; use ERGOLINES 1969-74
History Note: 65(63); METHYSERGIDE DERIVATIVES was see under METHYSERGIDE 1975-77; was see under ERGOLINES 1969-74
DeCS ID: 8973
Unique ID: D008784
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Methysergide - Preferred
Concept UI M0013673
Scope note An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Preferred term Methysergide
Entry term(s) Dimethylergometrin
Methylmethylergonovine
UML-491 - Narrower
Concept UI M0352827
Preferred term UML-491
Entry term(s) UML 491
UML491
Sansert - Narrower
Concept UI M0013675
Preferred term Sansert
Entry term(s) Deseril
Desril
Désernil Sandoz
Désernil-Sandoz
Methysergide Dimaleate - Narrower
Concept UI M0013674
Preferred term Methysergide Dimaleate
Entry term(s) Dimaleate, Methysergide
Methysergide Maleate - Narrower
Concept UI M0352828
Preferred term Methysergide Maleate
Entry term(s) Maleate, Methysergide



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