Descriptors Found: 1
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Descriptor English:   Mutagenesis, Insertional 
Descriptor Spanish:   Mutagénesis Insercional 
Descriptor Portuguese:   Mutagênese Insercional 
Synonyms English:   Activation, Insertional
Activations, Insertional
Cassette Mutagenesis
Gene Insertion
Gene Insertions
Insertion Mutation
Insertion Mutations
Insertion, Gene
Insertion, Sequence
Insertional Activation
Insertional Activations
Insertional Mutagenesis
Insertional Mutagenesis, Viral
Insertions, Gene
Insertions, Sequence
Linker Insertion Mutagenesis
Linker-Insertion Mutagenesis
Mutagenesis, Cassette
Mutagenesis, Linker-Insertion
Mutagenesis, Viral Insertional
Mutation, Insertion
Mutations, Insertion
Sequence Insertion
Sequence Insertions
Viral Insertional Mutagenesis  
Tree Number:   E05.393.420.601.550
Definition English:   Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation. 
See Related English:   DNA Transposable Elements
History Note English:   91 
Allowable Qualifiers English:  
DE drug effects EC economics
GE genetics HI history
IM immunology IS instrumentation
MT methods PH physiology
RE radiation effects ST standards
SN statistics & numerical data  
Record Number:   29057 
Unique Identifier:   D016254 

Occurrence in VHL: