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Descriptor English: Nomifensine
Descriptor Spanish: Nomifensina
Descriptor nomifensina
Scope note: Derivado de la isoquinolina que previene la recaptación de dopamina en los sinaptosomas. El maleato fue originalmente utilizado en el tratamiento de la depresión. En 1986 fue retirado, a nivel mundial, debido al riesgo de anemia hemolítica aguda con hemolisis intravascular resultante de su uso. En algunos casos, también se desarrollaba insuficiencia renal.
Descriptor Portuguese: Nomifensina
Descriptor French: Nomifensine
Entry term(s): Hoe 984
Hoe-984
Hoe984
Linamiphen
Maleate, Nomifensine
Merital
Nomifensin
Nomifensine Maleate
Nomifensine Maleate (1:1)
Tree number(s): D03.633.100.531.535
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009627
Scope note: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Dopamine Uptake Inhibitors
Registry Number: 1LGS5JRP31
CAS Type 1 Name: 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
Previous Indexing: Isoquinolines (1969-1977)
Quinolines (1966-1968)
Public MeSH Note: 86; was see under ISOQUINOLINES 1978-85
History Note: 86(78); was see under ISOQUINOLINES 1978-85
DeCS ID: 24345
Unique ID: D009627
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1977/04/22
Revision Date: 2016/05/31
Nomifensine - Preferred
Concept UI M0014947
Scope note An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Preferred term Nomifensine
Entry term(s) Linamiphen
Nomifensin
Nomifensine Maleate - Narrower
Concept UI M0353764
Preferred term Nomifensine Maleate
Entry term(s) Maleate, Nomifensine
Nomifensine Maleate (1:1)
Hoe-984 - Narrower
Concept UI M0014948
Preferred term Hoe-984
Entry term(s) Hoe 984
Hoe984
Merital - Narrower
Concept UI M0353765
Preferred term Merital



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