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Descriptor English:   Oncogene Proteins v-erbA 
Descriptor Spanish:   Proteínas Oncogénicas v-erbA 
Descriptor Portuguese:   Proteínas Oncogênicas v-erbA 
Synonyms English:   Oncogene Products v erbA
Oncogene Products v-erbA
Oncogene Proteins v erbA
erbA Oncogene Proteins
v erbA Proteins
v-erbA Proteins  
Tree Number:   D12.776.624.664.520.750.882
Definition English:   Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation. 
History Note English:   95; was ONCOGENE PROTEIN ERBA (NM) 1987-94 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   32106 
Unique Identifier:   D018774 

Occurrence in VHL: