Search on: OSTEOCALCIN 
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Descriptor English:   Osteocalcin 
Descriptor Spanish:   Osteocalcina 
Descriptor Portuguese:   Osteocalcina 
Synonyms English:   4 Carboxyglutamic Protein, Bone
4-Carboxyglutamic Protein, Bone
Bone 4-Carboxyglutamic Protein
Bone Gla Protein
Bone gamma Carboxyglutamic Acid Protein
Bone gamma-Carboxyglutamic Acid Protein
Calcium Binding Protein, Vitamin K Dependent
Calcium-Binding Protein, Vitamin K-Dependent
Gla Protein, Bone
Protein, Bone 4-Carboxyglutamic
Protein, Bone Gla
Vitamin K Dependent Bone Protein
Vitamin K-Dependent Bone Protein  
Tree Number:   D12.776.157.125.700
Definition English:   Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX. 
History Note English:   90; GLA-PROTEIN was see OSTEOCACLIN 1990-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   24820 
Unique Identifier:   D015675 

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