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Descriptor English: Pituitary Adenylate Cyclase-Activating Polypeptide
Descriptor Spanish: Polipéptido Hipofisario Activador de la Adenilato-Ciclasa
Descriptor polipéptido hipofisario activador de la adenilato ciclasa
Entry term(s) PACAP
polipéptido activador de la adenilato ciclasa hipofisario
Scope note: Neuropéptido multifuncional que actúa en todo el organismo elevando el nivel de AMP cíclico intracelular mediante su interacción con los RECEPTORES DEL PACAP y con los RECEPTORES DEL PÉPTIDO INTESTINAL VASOACTIVO. Aunque se aisló por primera vez a partir de extractos hipotalámicos y se denominó por su acción sobre la hipófisis, tiene una amplia distribución por los sistemas nerviosos central y periférico. El PACAP es importante en el control de procesos endocrinos y homeostáticos, como la secreción de hormonas hipofisarias e intestinales y la ingesta de alimentos.
Descriptor Portuguese: Polipeptídeo Hipofisário Ativador de Adenilato Ciclase
Descriptor French: Polypeptide activateur de l'adénylcyclase hypophysaire
Entry term(s): PACAP
PACAP-27
PACAP-38
PACAP27
PACAP38
Pituitary Adenylate Cyclase Activating Polypeptide
Pituitary Adenylate Cyclase Activating Polypeptide 27
Pituitary Adenylate Cyclase Activating Polypeptide 38
Tree number(s): D12.644.276.860.887
D12.644.400.625
D12.776.467.860.887
D12.776.631.600.887
D12.776.631.650.625
D23.529.850.887
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051219
Scope note: A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS and VASOACTIVE INTESTINAL PEPTIDE RECEPTOR. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Growth Substances
Vasodilator Agents
Neurotransmitter Agents
Public MeSH Note: 2006; PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE was indexed under NERVE GROWTH FACTORS & NEUROPEPTIDES & NEUROTRANSMITTERS 1990-2005
History Note: 2006(1990)
DeCS ID: 50569
Unique ID: D051219
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/06/17
Pituitary Adenylate Cyclase-Activating Polypeptide - Preferred
Concept UI M0173008
Scope note A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS and VASOACTIVE INTESTINAL PEPTIDE RECEPTOR. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.
Preferred term Pituitary Adenylate Cyclase-Activating Polypeptide
Entry term(s) PACAP
Pituitary Adenylate Cyclase Activating Polypeptide
Pituitary Adenylate Cyclase Activating Polypeptide 38 - Narrower
Concept UI M0456497
Preferred term Pituitary Adenylate Cyclase Activating Polypeptide 38
Entry term(s) PACAP-38
PACAP38
Pituitary Adenylate Cyclase Activating Polypeptide 27 - Narrower
Concept UI M0456496
Preferred term Pituitary Adenylate Cyclase Activating Polypeptide 27
Entry term(s) PACAP-27
PACAP27



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