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Descriptor English: Tolvaptan
Descriptor Spanish: Tolvaptán
Descriptor tolvaptán
Entry term(s) 7-cloro-5-hidroxi-1-(2-metil-4-(2-metilbenzoilamino)benzoil)2,3,4,5-tetrahidro-1H-1-benzazepina
OPC 41061
OPC-41061
OPC41061
Samsca
Scope note: Derivado benzacepínico y antagonista selectivo de los RECEPTORES DE VASOPRESINA V2 que se usa para tratar la HIPONATREMIA euvolémica e hipervolémica. También se usa en el tratamiento del RIÑÓN POLIQUÍSTICO AUTOSÓMICO DOMINANTE de progresión rápida para ralentizar el desarrollo de los quistes y la insuficiencia renal.
Descriptor Portuguese: Tolvaptan
Descriptor French: Tolvaptan
Entry term(s): 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
OPC 41061
OPC-41061
OPC41061
Samsca
Tree number(s): D03.633.100.079.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077602
Scope note: A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antidiuretic Hormone Receptor Antagonists
Registry Number: 21G72T1950
CAS Type 1 Name: Benzamide, N-(4-((7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-3-methylphenyl)-2-methyl-
Public MeSH Note: 2019; TOLVAPTAN was indexed under BENZAZEPINES 1999-2019
History Note: 2019 (1999)
DeCS ID: 57705
Unique ID: D000077602
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Tolvaptan - Preferred
Concept UI M0299851
Scope note A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.
Preferred term Tolvaptan
Entry term(s) 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
Samsca - Narrower
Concept UI M0539217
Preferred term Samsca
OPC 41061 - Narrower
Concept UI M0450903
Preferred term OPC 41061
Entry term(s) OPC-41061
OPC41061



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