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Descriptor English: Suramin
Descriptor Spanish: Suramina
Descriptor suramina
Scope note: Compuesto polianiónico con un mecanismo de acción desconocido. Se utiliza parenteralmente en el tratamiento de la tripanosomiasis africana y ha sido utilizado clínicamente con la dietilcarbamazina para matar los Oncocercos adultos. (AMA Drug Evaluations Annual, 1992, p1643) También se ha demostrado que posee potentes propiedades antineoplásicas.
Descriptor Portuguese: Suramina
Descriptor French: Suramine
Entry term(s): Germanin
Hexasodium Salt Suramin
Monosodium Salt Suramin
Moranil
Naganin
Naganol
Naphuride
Salt Suramin, Hexasodium
Salt Suramin, Monosodium
Sodium, Suramin
Suramin Sodium
Suramin, Hexasodium Salt
Suramin, Monosodium Salt
Tree number(s): D02.455.426.559.847.638.555.750
D02.886.645.600.080.050.650.750
D04.615.638.555.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013498
Scope note: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antinematodal Agents
Antineoplastic Agents
Trypanocidal Agents
Registry Number: 6032D45BEM
CAS Type 1 Name: 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-
DeCS ID: 13879
Unique ID: D013498
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Suramin - Preferred
Concept UI M0020853
Scope note A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Preferred term Suramin
Germanin - Narrower
Concept UI M0020854
Preferred term Germanin
Suramin Sodium - Narrower
Concept UI M0329624
Preferred term Suramin Sodium
Entry term(s) Hexasodium Salt Suramin
Salt Suramin, Hexasodium
Sodium, Suramin
Suramin, Hexasodium Salt
Naganin - Narrower
Concept UI M0351762
Preferred term Naganin
Naganol - Narrower
Concept UI M0351763
Preferred term Naganol
Naphuride - Narrower
Concept UI M0351764
Preferred term Naphuride
Suramin, Monosodium Salt - Narrower
Concept UI M0329625
Preferred term Suramin, Monosodium Salt
Entry term(s) Monosodium Salt Suramin
Salt Suramin, Monosodium
Moranil - Narrower
Concept UI M0351761
Preferred term Moranil



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