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Descriptor English: Tolcapone
Descriptor Spanish: Tolcapona
Descriptor tolcapona
Entry term(s) 3,4 dihidroxi 5' metil 5 nitrobenzofenona
3,4-dihidroxi-5'-metil-5-nitrobenzofenona
Ro 40 7592
Ro 40-7592
Ro 407592
Ro-40-7592
Ro407592
SOM0226
Tasmar
Scope note: Compuesto de benzofenona y nitrofenol que actúa como inhibidor de la CATECOL O-METILTRANSFERASA, una enzima que interviene en el metabolismo de la DOPAMINA y de la LEVODOPA. Se usa en el tratamiento de la ENFERMEDAD DE PARKINSON en pacientes en los que la levodopa no es eficaz o está contraindicada.
Descriptor Portuguese: Tolcapona
Descriptor French: Tolcapone
Entry term(s): 3,4 Dihydroxy 5' methyl 5 nitrobenzophenone
3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone
Ro 40 7592
Ro 40-7592
Ro 407592
Ro-40-7592
Ro407592
SOM0226
Tasmar
Tree number(s): D02.455.426.559.389.134.875
D02.455.426.559.389.657.566.845
D02.522.223.875
D02.640.743.845
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077867
Scope note: A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiparkinson Agents
Catechol O-Methyltransferase Inhibitors
Registry Number: CIF6334OLY
CAS Type 1 Name: Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
Public MeSH Note: 2019; TOLCAPONE was indexed under BENZOPHENONES and NITROPHENOLS 1990-2018
History Note: 2019 (1990)
DeCS ID: 57770
Unique ID: D000077867
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21
Tolcapone - Preferred
Concept UI M0182081
Scope note A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.
Preferred term Tolcapone
3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone - Related but not broader or narrower
Concept UI M000642026
Preferred term 3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone
Entry term(s) 3,4 Dihydroxy 5' methyl 5 nitrobenzophenone
SOM0226 - Narrower
Concept UI M000600978
Preferred term SOM0226
Ro 40-7592 - Narrower
Concept UI M0182079
Preferred term Ro 40-7592
Entry term(s) Ro 40 7592
Ro 407592
Ro-40-7592
Ro407592
Tasmar - Narrower
Concept UI M0357196
Preferred term Tasmar



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