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Descriptor English: Trabectedin
Descriptor Spanish: Trabectedina
Descriptor trabectedina
Entry term(s) ET 743
ET-743
ET743
NSC 684766
ecteinascidina 743
yondelis
Scope note: Estructura compleja que incluye isoquinolinas unidas por un éster cíclico; es un fármaco que se une al ADN y un alquilante en la posición N2 de la guanina derivado del tunicado marino Ecteinascidia turbinata. La trabectedina se usa para el tratamiento del SARCOMA de tejidos blandos tras el fracaso de la farmacoterapia con ANTRACICLINAS o con IFOSFAMIDA.
Descriptor Portuguese: Trabectedina
Descriptor French: Trabectédine
Entry term(s): ET 743
ET-743
ET743
Ecteinascidin 743
NSC 684766
Yondelis
Tree number(s): D03.383.246.619
D03.633.100.531.820.781
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077606
Scope note: A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Alkylating
Registry Number: ID0YZQ2TCP
Public MeSH Note: 2019; TRABECTIDIN was indexed under DIOXOLES and TETRAHYDROISOQUINOLINES 2007-2018; and under ISOQUINOLINES 1996-2018
History Note: 2019 (1996)
DeCS ID: 57709
Unique ID: D000077606
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Trabectedin - Preferred
Concept UI M0453081
Scope note A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.
Preferred term Trabectedin
Yondelis - Narrower
Concept UI M0455084
Preferred term Yondelis
Ecteinascidin 743 - Narrower
Concept UI M0260321
Preferred term Ecteinascidin 743
Entry term(s) ET 743
ET-743
ET743
NSC 684766 - Narrower
Concept UI M0453082
Preferred term NSC 684766



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