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Descriptor English:   Vascular Endothelial Growth Factor A 
Descriptor Spanish:   Factor A de Crecimiento Endotelial Vascular 
Descriptor Portuguese:   Fator A de Crescimento do EndotÚlio Vascular 
Synonyms English:   GD-VEGF
Glioma Derived Vascular Endothelial Cell Growth Factor
Glioma-Derived Vascular Endothelial Cell Growth Factor
Permeability Factor, Vascular
Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor-A
Vascular Permeability Factor
Tree Number:   D12.644.276.100.800.200
Definition English:   The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced. 
History Note English:   2004; use VASCULAR ENDOTHELIAL GROWTH FACTOR A (NM) 2000-2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   38244 
Unique Identifier:   D042461 

Occurrence in VHL: