Search on: VERATRUM ALKALOIDS 
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Descriptor English:   Veratrum Alkaloids 
Descriptor Spanish:   Alcaloides de Veratrum 
Descriptor Portuguese:   Alcaloides de Veratrum 
Synonyms English:   Alkaloids, Veratrum  
Tree Number:   D03.132.920
Definition English:   Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects. 
Indexing Annotation English:   antihypertensives
Pharmacological Action:   Antihypertensive Agents
 
History Note English:   75 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   15109 
Unique Identifier:   D014704 

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