Search on: VIGABATRIN 
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Descriptor English:   Vigabatrin 
Descriptor Spanish:   Vigabatrin 
Descriptor Portuguese:   Vigabatrina 
Synonyms English:   Sabril
Sabrilex
gamma Vinyl GABA
gamma Vinyl gamma Aminobutyric Acid
gamma-Vinyl-GABA
gamma-Vinyl-gamma-Aminobutyric Acid  
Tree Number:   D02.241.081.114.500.350.900
D12.125.190.350.900
Definition English:   An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA-AMINOBUTYRIC ACID and is used as an anticonvulsant. (From Martindale The Extra Pharmacopoeia, 31st ed) 
Pharmacological Action:   Anticonvulsants
Enzyme Inhibitors
GABA Agents
 
History Note English:   2000; use VIGABATRIN 1977-1999 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   34388 
Unique Identifier:   D020888 

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